During the COVID-19 crisis, Anton Paar has received enquiries from many instrument users whether their existing Anton Paar instrumentation is also suitable when manufacturing hand sanitizers to support their local community. The wetted parts of Anton Paar density meters are resistant towards all ingredients used to produce hand sanitizers.
We have put together some brief tips below on how to use your Anton Paar Density meter for these purposes. These ingredients are
- ethanol (EtOH) 96 % diluted to a final concentrations of 80 %v/v or
- isopropyl alcohol (IPA) 99.8 % in %v/v – diluted to a final concentrations of or 75 %v/v for IPA
- Hydrogen peroxide (H2O2),
- glycerol, and
- sterile/boiled water
Anton Paar density meters are suitable to check both, the ethanol-based and isopropyl alcohol-based formulations described by WHO and FDA (see references below).
All Anton Paar density meters are equipped with the required custom functions or tables for concentration checks of ethanol and isopropyl alcohol to automatically convert the density into the concentration unit and display it on the instruments’ screen.
1.1 Ethanol-based hand sanitizers
- All DMA density meters can convert the density into ethanol concentrations in %v/v.
- Use the Ethanol function to get the concentration reading. Make sure to use the same function corresponding to local regulatory requirements at all stages measuring ethanol (raw material & final product). The result displayed will refer to the reference temperature of the used function.
- The small addition of glycerol and hydrogen peroxide will result in a slightly lower reading than the actual ethanol concentration in the final product. Accuracy is within WHO accepted limits.
1.2 IPA-based hand sanitizers
- All DMA density meters can convert the density into isopropyl alcohol concentrations in %v/v.
- Use the IPA custom function to get the concentration reading. Make sure to use the same function at all stages measuring IPA (raw material & final product). The IPA table for % v/v is based on a sample temperature of 20°C. Significant different sample temperature may give a deviation to actual IPA content.
- The small addition of glycerol and hydrogen peroxide will result in a slightly lower reading than the actual IPA concentration in the final product. Accuracy is within WHO accepted limits.
1.3 Checking glycerol and hydrogen peroxide
- Use the respective custom functions for glycerol and hydrogen peroxide to get the concentration reading.
For the exact formulation and instructions on how to prepare hand sanitizers please follow the instructions given in:
- WHO hand sanitizer local production guidelines https://www.who.int/gpsc/5may/Guide_to_Local_Production.pdf
- FDA guidelines https://www.fda.gov/media/136118/download
If you want to know the amount of ingredients for a targeted volume of product or how much product you get with an available amount of ethanol or IPA, use the calculator (Excel File in the package with the custom functions and tables).
Do you have additional questions? Contact us via email at email@example.com or through the local subsidiary/distribution partner. Contact details are available through www.anton-paar.com.